Pipeline

EVOLVE-104 is a first-in-class biotherapeutic with potential to address a wide range of solid tumors with high selectivity. EVOLVE-105 represents a best- in-class molecule to improve patient outcomes in relapsed or treatment refractory B cell lymphoma.  Our best-in-class EVOLVE-106 program addresses important unmet needs in selected solid tumor targets. EVOLVE-101 is a first-in-class molecule targeting a novel tumor antigen for the treatment of B cell malignancies and particular myeloid malignancies.  We anticipate entering the clinic with our first program in 2024.

PROGRAM
INDICATIONS
Discovery
LEAD OPTIMIZATION
IND-ENABLING
Phase 1

Internal Programs

EVOLVE104

Target: ULBP2/5/6
Bladder, NSCLC, squamous cancers
  • Discovery
  • Lead Optimization
  • IND-Enabling
  • Phase 1

EVOLVE205

Target: CD20
Autoimmune diseases
& DLBCL
  • Discovery
  • Lead Optimization
  • IND-Enabling
  • Phase 1

EVOLVE220

CRPC
  • Discovery
  • Lead Optimization
  • IND-Enabling
  • Phase 1

Partnered Programs

EVOLVE108

Undisclosed
  • Discovery
  • Lead Optimization
  • IND-Enabling
  • Phase 1

EVOLVE109

Undisclosed
  • Discovery
  • Lead Optimization
  • IND-Enabling
  • Phase 1