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Research Associate 1

Apr 20 2022

Who We Are

EvolveImmune Therapeutics is a next-generation immunotherapy platform company based in the Yale/New Haven biotechnology ecosystem with laboratories in Branford and Farmington, CT.  EvolveImmune is harnessing its ‘Immunology First’ approach to create first-in-category cancer medicines which aim to transform the lives of patients by delivering superior, long-term outcomes compared to current anti-cancer therapies. The EvolveImmune team has established a first-in-class and highly differentiated tumor-targeted T cell costimulation platform designed to re-invigorate adaptive immune responses in solid tumors.  In addition, building upon research that originated from the Sidi Chen Laboratory at Yale University, EvolveImmune is leveraging a novel in vivo CRISPR-based target discovery platform to develop a broad portfolio of first-in-class therapeutics for unmet needs in oncology and immune diseases. The EvolveImmune team has 16,000+ square feet of custom-built lab and office space in Branford, CT to support biological development and clinical translational of programs advancing to the clinic.

For more information about EvolveImmune Therapeutics, please visit https://evolveimmune.com/.

The Role

We have a position opening for Research Associate in the Biology team.  The ideal candidate has a strong positive attitude and a willingness to learn with general laboratory experience that may include material and reagent preparation using sterile techniques, evaluation of recombinant proteins in biophysical and functional assay, cell culture, and the isolation and evaluation of primary human immune cells.

This individual will work directly with the drug development project team to evaluate novel cancer immunotherapies designed to orchestrate adaptive immunity through optimal T cell activation at tumor sites.  This includes helping to prepare materials and reagents for experiments, assisting with primary lymphocyte isolation, evaluating the potential novel immunotherapies to prevent or reverse T cell exhaustion in ex vivo assays, and establishing immune cell cancer cell co-cultures assays for ex vivo evaluation of novel antibody-based immunotherapies.  This individual will also help stage materials of in vivo studies by expanding cancer cell cultures and preparing immune cell materials to evaluate surrogate immunotherapies in mouse models of cancer.  Accurate data recording, strong attention to details and the ability to follow standard procedures are critical for success in this role.

We are looking for candidates who enjoy working in a team and can leverage the growth opportunities that a matrixed environment provides. This is an exceptional opportunity for someone who is excited about drug discovery and development and is driven to translate our discoveries into novel therapeutics.

Responsibilities

  • Collaborate with team members across different functional teams
  • Maintain tissue cultured cancer cell lines
  • Immune cell isolation human PBMCs preparation
  • Specific human immune cell isolation
  • Execution of immune cell activation assays
  • Acquisition of cellular assay measurements that include cell toxicity, protein and cytokine measurements by Enzyme-linked immunosorbent assay (ELISA) and Meso-Scale Device and cell surface marker assessment by immunofluorescent antiobody staining and flow cytometry.
  • Perform image-based acquisition and analysis of cellular assays
  • Keep detailed records of experiments in electronic notebooks, analyze data and prepare and deliver presentations to research team members.
  • This role is a full time, in-person position in EvolveImmune’s laboratories in Branford CT.

Qualifications

B.S./B.A. degree in biology or a related field, with 1-3 years of laboratory experience in the biotech/pharmaceutical industry or in an academic institution.

Experience

The candidate should have general laboratory experience with a preference for candidates that that have experience in cancer biology and cellular immunology.  Experience with general procedures including experience in aseptic tissue culture techniques, enzyme-linked immunosorbent assay (ELISA), cell phenotyping or enumeration using flow cytometry and lab safety procedures is preferred.  Data analysis experience with GraphPad Prism and general knowledge of routine statistical analysis is also preferred.

EvolveImmune Therapeutics requires all employees to be fully vaccinated against COVID-19.

EvolveImmune Therapeutics is an equal opportunity employer.

Principals only.

Qualified applicants should apply using this link.